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Arterial stiffness was measured by gold standard pulse wave velocity using the SphygmoCor system (SphygmoCor Mx, AtCor Medical, Sydney, Australia, version 6.31) 51

The half-life difference between the two forms is roughly 8 days versus minutes, so the dosing frequency mismatch is dramatic

Interagency Pain Research Coordinating Committee

Similarly, preclinical research involving animals must comply with Institutional Animal Care and Use Committee (IACUC) directives and adhere to Animal Welfare Act (AWA) standards