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Appropriate FAD-dependent enzyme activity is likewise essential for bloodbrain barrier integrity: deficits in flavin enzyme function compromise endothelial tight junctions, increasing barrier permeability and facilitating neuroinflammatory propagation

Among these, artesunate, sevoflurane, dihydroartemisinin, brusatol, nisin, hederagenin, glaucocalyxin A, nootkatone, cannabinoids and ophiopogonin B successfully promote ferroptosis in diverse cancer cell types mediated by the ER stress branch ATF4-CHOP-CHAC1 (Lu et al., 2024