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Description

IV administration carries anaphylaxis risk

We followed up on two hits that exhibited the strongest GxE interactions, SLC25A19 and SLC25A32, which are transporters of two B family vitamin-derived cofactors, thiamine pyrophosphate (ThPP, or vitamin B 1 ) and folate species (vitamin B 9 ), respectively

Bicarbonate or buffering agents for metabolic acidosis (due to elevated lactate or ketosis) at 0.5 to 2.5 mEq/kg/day is necessary for individuals with pyruvate dehydrogenase complex deficiency, particularly those on ketogenic diet