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Additionally, the -1-hydroxilase enzyme, which converts inactive metabolite of VD (25(OH) D3) to the active form (1,25(OH)2D3), is expressed by the majority of immune cells such as macrophages [112]

A history of active cancer is a major contraindication for these therapies, as growth-stimulating hormones could theoretically influence tumor growth

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DGUOK mediates the phosphorylation of deoxyguanosine and deoxyadenosinepurine into the corresponding nucleotides in mitochondria and its deficiency creates an imbalance in the mitochondrial dNTPs pool that affects mtDNA synthesis