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Evidence from clinical studies suggests that VE, either alone or in combination with other compounds, can significantly reduce pro-inflammatory cytokines such as IL-6, TGF-1, and MCP-1, while enhancing anti-inflammatory mediators including IL-10 and adiponectin

This work was supported by EU grant QLG 1-CT-1999-00739 and Wilhelm Sander-Stiftung grant 2002.045.1

6 Similarly, conditions such as osteoporosis and certain neurological disorders have also shown links to dietary patterns, highlighting the broad influence of diet on overall health

The copper chaperone ATOX1 is a particularly compelling target in this context