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Griffith JL, Wong M

GST enzymes are essential in detoxifying endogenous or exogenous toxic compounds by catalyzing the conjugation of the nucleophilic thiol group from reduced GSH to co-substrates possessing an electrophilic center

When you increase a single-agonist like semaglutide, you are ramping one pathway

For example, a 2025 observational study that included data from 58 subjects with RLS found the response to IV iron therapy was similar in those with ferritin levels between 100 and 300 ng/mL and those with levels under 100 ng/mL (Garcia-Malo 2025)