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10.4161/auto.4451 Autophagy 47 KingM

Except for a few isolated cases, no definitive factors capable of triggering the pathological process have been identified

By constructing humanized animal models to modify the host, such as transplanting human hematopoietic stem cells or human liver cells into immunodeficient mice to carry functional human immune cells or target organs, the interaction between engineered bacteria and human cells can be evaluated in a living environment

Since lumping emphasizes hidden causes rather than visible effects, it may get us further along the path of recognizing the modifiable etiological factors of neurodegeneration that are crucial for guiding prevention and therapy