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However, even the RDA for vitamin C, which is old of course, but the RDA for vitamin C is based partly on the fact that there are consistent observational studies showing that there are, there is a certain plasma level of vitamin C that is associated with the lowest risk of cardiovascular disease and a handful of certain diseases that seem to correlate with vitamin C levels

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and Fessler, J.H., "Peroxidasin: a novel enzyme-matrix protein of Drosophila development", EMBO Journal 13: 3438-3447 (1994)