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Kim J, Cha Y-N, Surh Y-J (2010) A protective role of nuclear factor-erythroid 2-related factor-2 (Nrf2) in inflammatory disorders

Subsequently, pharmacologic inhibition of CD38 in LPS and IFN stimulated primary human astrocytes, phenocopied the murine studies and showed that the inhibition of NAD + hydrolysis in these cells, decreased chemokine signaling (72), supporting that astrocytic NAD + biology may play an important role in human neuroinflammation

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But the mechanistic rationale is strong, and early anecdotal reports from researchers and clinics using the combination suggest meaningful improvements in appetite control, energy expenditure, and overall metabolic response compared to retatrutide alone