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Conditionally pathogenic bacteria in the oral cavity ( Fusobacterium nucleatum and Porphyromonas gingivalis ) can migrate to the intestine through swallowing or blood circulation, for example, dysbiosis of the oral flora caused by periodontal inflammation can weaken the resistance to intestinal colonization and exacerbate the pathological process of inflammatory bowel disease by disrupting the intestinal barrier function ( Helicobacter pylori can ectopically colonize the oral cavity through bloodstream, and its induced inflammatory cytokines (such as IL-8, TNF-) directly disrupt the oral immune microenvironment and promote local inflammatory responses in diseases such as oral lichen planus ( 3 The relationship between oral-intestinal microbes and oral mucosal diseases 3.1 Oral mucosal diseases Oral diseases are an important public health issue, and prevalence, which affects all age groups, has a significant negative impact on quality of life ( Oral mucosal diseases, common including infectious diseases (including oral candidiasis and oral herpes) and non-infectious inflammatory diseases (including oral lichen planus and recurrent aphthous stomatitis), may pose a significant threat to oral health (Figure 1