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This clinical review critically examines the strengths and limitations of RCTs and RWE, synthesizing statistical findings and published literature to clarify their respective contributions to evidence development

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Proteostasis: maintenance of protein homeostasis in cells, involving processes that regulate protein synthesis, folding, degradation, and clearance to ensure proper protein function and prevent cellular dysfunction and disease

This intervention reduced lipid peroxidation and enhances cellular resistance to ferroptosis, highlighting a novel mechanism by which PPARa protects against ferroptotic cell death