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The four subclasses of IgG [1,2,3,4] have differing capacities to engage FcRn and other immune effector molecules [129, 130], and which subclass that drives pathology differs across autoimmune diseases

HSP70s may be stress inducible or not inducible and reside in different cell sites at different concentrations, thereby affecting their function

Additionally, pharmaceutical companies can use contract manufacturing, which is also called third-party manufacturing, to delegate their entire production operations to established manufacturers who operate state-of-the-art production facilities and hold necessary industry certifications and employ qualified personnel