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We conducted systematic searches of PubMed/Medline, EMBASE, and Cochrane Library using keywords: (brain-gut-microbiota axis OR microbiota-gut-brain axis) AND (dysbiosis OR neuroinflammation OR SCFAs OR probiotics OR fecal microbiota transplantation)

This evolutionary perspective provides a conceptual framework for understanding why specific metabolic enzymes have become integral components of epigenetic regulation, setting the stage for the following discussion of oxidoreductase-mediated mechanisms