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de Kloet ER, Jols M, Holsboer F

Moreover, a diet supplemented with EA mitigates oxidative stress during colitis by bolstering Nrf2 signaling pathways in piglets treated with paraquat, protecting against intestinal injury by facilitating the maintenance of tight junction structure and intestinal barrier integrity, while also preserving jejunal and ileal morphology, including villus height, goblet cell number, and the ratio of villus height to crypt depth [349]

When glutathione stores are depleted by overproduction of this metabolite, however, the reactive metabolite binds to liver cell proteins and causes hepatic necrosis

For example, the framing of Safe System approaches often narrows its focus to reducing harm within a car-dependent framework, implicitly endorsing the principle that any amount of vehicle driving is acceptable as long as no one is killed or severely injured. This reveals a lack of genuine systems thinking, despite the use of the word "system" in its title