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The major difference is that whereas only the main chain carboxylate of wild-type Thr1273 interacts with basic Lys17 on the WD40 surface, both the side chain and main chain carboxylate groups of the clientized Glu1273 residue form extensive interactions with a WD40 basic cluster of Arg15, Lys17, and Arg272 (Fig

Wound healing A The exact science of how this works is not clear, but researchers theorize it may also be connected to the antioxidant and anti-inflammatory properties of thymoquinone

Science 232 , 3447 (1986)

From a translational perspective, integration of PWE or related polyphenol-rich formulations into preventive or early-intervention strategies, alone or in combination with standard pharmacotherapies, warrants investigation to define efficacy, safety, optimal dosing and patient subsets most likely to benefit