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doi: 10.3389/fmicb.2020.00928 80 NazS.GulA.ZiaM

This triple agonism produces greater weight loss but raises questions about whether additional mechanisms might affect thyroid safety differently

Experimental autoimmune thyroiditis (EAT) models have demonstrated that pharmacological blockade of S1P signaling ameliorates thyroid inflammation and reduces TSH levels, underscoring a bidirectional crosstalk between thyroid dysfunction and liver inflammation via ECM pathways (93)