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Upregulation of TET2 and resistance to DNA methyltransferase (DNMT) inhibitors in DNMT1-deleted cancer cells

The nigrostriatal pathway is particularly vulnerable to oxidative stress, neuroinflammation, and genetic mutations (e.g., parkin) due to its high synaptic density, extensive unmyelinated axonal networks, and elevated metabolic demands (Hegarty et al., 2013