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Spermatozoa are highly vulnerable to oxidative stress owing to limited levels of antioxidant defence and a single, limited DNA-damage detection and repair mechanism

Nat Rev Immunol 13 , 349361 (2013)

As seen from Figure 3A (gray bars), the GSH decrease becomes insignificant in the thiamine-treated LE and SCI animals, compared with the non-operated control animals, whose GSH content is independent of thiamine