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In adults, the peptide is actually heavily modified in the brain to make it shorter, indicating that analogues like IGF-1 DES may have better therapeutic potential than intact IGF-1

Neurology 2020;95(19):e2622-e2634 Seung Wan Suh, Ji Won Han, Ji Hyun Han, Jong Bin Bae, Woori Moon, Hye Sung Kim, Dae Jong Oh, Kyung Phil Kwak, Bong Jo Kim, Shin Gyeom Kim, Jeong Lan Kim, Tae Hui Kim, Seung-Ho Ryu, Seok Woo Moon, Joon Hyuk Park, Seonjeong Byun, Jiyeong Seo, Jong Chul Youn, Dong Young Lee, Dong Woo Lee, Seok Bum Lee, Jung Jae Lee, Jin Hyeong Jhoo, Ki Woong Kim Sex differences in subjective age-associated changes in sleep: a prospective elderly cohort study