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Another major use of methyl groups in the body is for the synthesis of phosphatidylcholine from choline, so when phosphatidylcholine levels are higher, there is less of a strain on the methylation cycle.[ref] Where is homocysteine produced

Furthermore, APP/PS1 mice exhibit significant hyperactivity in the dorsal raphe nucleus during reward-seeking and motivational actions (Sakurai et al., 2020), indicating complex interactions between A pathology and neural circuitry affecting behavior