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The reason retatrutide and the approved GLP-1s are titrated up over months is side effects: in the Phase 2 trial, jumping to high doses without titration nearly doubled gastrointestinal side effects for the same weight loss (The Lancet, 2023)

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The collagen, anti-aging and healing claims rest largely on topical, in-vitro and animal data

Mechanism 3: Collagen Organization and Remodeling Animal and human studies show BPC-157 promotes: Better collagen fiber organization Improved mechanical properties of healing tissue More cross-linking between collagen fibers Stronger, more resilient repair Instead of just growing more tissue, BPC-157 appears to help organize it in a functionally superior way