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Protein labeling - biotinylate antibodies to facilitate immobilization, purification or detection using streptavidin resins or probes Cell surface labeling - biotinylates only surface proteins of whole cells because the negatively charged reagent does not permeate cell membranes Amine-reactive - reacts with primary amines (-NH2), such as lysine side-chains, or the amino-termini of polypeptides Soluble - charged sulfo-NHS group increases reagent water solubility compared to ordinary NHS-ester compounds Irreversible - forms permanent amide bonds

Fortunately, extensive global data indicates that this therapeutic agent presents an excellent safety profile with minimal reported issues

Daneva et al., 2016)