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It is also possible that damage via the carbonyl stress pathway may only occur at a local level limited to renal tissue

Further findings (102) reveal that iron overload leads to the increase of MMP and the accumulation of lipid peroxide by affecting GSH and fatty acid cycle, which further promotes the activation of osteoclasts and apoptosis of osteoblasts, leading to increased bone resorption and decreased bone formation

The evidence base discussed reflects the current peer-reviewed literature

Women on hormone replacement therapy should consult their prescribing physician at least annually to assess whether continued hormone therapy is appropriate