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Expression of the mutant human B-crystallin in mice resulted in a cardiomyopathy, with progressive heart failure, and sudden, premature death

Cammilleri G, et al

53,54 However, it has also been suggested that the enhanced release of proinflammatory cytokines (TNF-, IL-1, IL-6, and IL-10) and chemokines (monocyte chemoattractant protein-1, macrophage inflammatory protein-2, and IL-8) further promotes hepatocyte damage, thereby aggravating necrosis

Next, we supplied [ 13 C 6 ]Arg, [ 13 C 5 ]Gln, [ 13 C 6 ]glucose (Glc) or [ 13 C 4 ]Put as metabolic tracers in the culture medium and followed 13 C incorporation into individual metabolites by GCMS