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Conclusion and perspectives: selenium metabolism-based therapeutic strategies for treating arthropathies This review discussed the roles of selenium metabolism in cartilage development and arthropathies such as KBD and OA, and highlighted its crucial functions in maintaining cartilage homeostasis

( 2 O 2 , a potent ROS-inducer, and superoxide dismutase (SOD), a natural antioxidant agent, were higher in GO then control OFs, whereas the ROS antagonist glutathione peroxidase (GPX) was reduced, with a reduced ratio between glutathione and oxidized glutathione, suggesting the presence of a remarkable state of oxidative stress ( Glycosaminoglycan Production and Heat Shock Protein 72 Expression in Orbital fibroblasts As mentioned above, the release of GAGs plays an important role in the pathogenesis of GO

In contrast to other mammals, humans have developed a unique immune system, due to the lack of an innate immune response to HBV (including interferons, interleukins, tumor necrosis factor, etc.) (Wieland et al., 2004)