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33 , 10011012.e5 (2021)

The process of beta-cell death appears to be enhanced by A1AT deficiency (109)

Nevertheless, the causal relationships between gut microbiota and thyroid diseases, how gut microbiota modulates thyroid autoimmunity, and the specific mechanisms by which a particular bacterium or core flora triggers thyroid diseases, are still poorly understood

Methods: Paired-biopsy samples from the GAN DIO-NASH-HCC model (52 weeks of diet) treated for 16 weeks with either vehicle, 30 mg/kg lanifibranor or 30 nmol/kg semaglutide (N=15-17 animals/group) were included