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The steps in anaerobic glycolysis are summarised in Figure 3.1 Characteristics of Australian mammals The concentrations of glycolytic metabolites and activities of various glycolytic enzymes have been measured in many marsupials and the monotremes

( 2+ and ROS, and mitigating peroxidative damage ( While current studies have delineated the core roles of ferroptosis (via the System Xc GSHGPX4 axis, iron overload, lipid peroxidation, and mitochondrial dysfunction) and identified antioxidant networks (Nrf2/Sirtuins/FTH1) as therapeutic targets in DN, several critical research gaps persist that hinder a comprehensive understanding of ferroptosis-driven DN progression and translational application