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In addition, other reports have shown that PLX5622 can also deplete lung interstitial macrophages, splenic macrophages, and patrolling monocytes within the CNS, and that PLX5622 alleviates pulmonary fungal infection in mice by depleting MHCII [16] . Further studies indicate that the inhibitory effects of PLX5622 are not limited to microglia, but also extend to peripheral macrophages in the liver, perivascular macrophages (PVMs), and myeloid and lymphoid cells in the bone marrow, spleen, and blood [17][18] . Q2 What is the shelf life of PLX5622 when formulated into chow