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Early clinical studies suggest that retatrutide may improve cardiometabolic profiles by reducing blood pressure and improving lipid levels, further underscoring its promise for addressing both metabolic and cardiovascular risk factors in individuals with obesity and diabetes

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The Leyden 2002 facial-cream trial reported skin density, thickness, fine lines, and laxity changes at 12 weeks

171,172 In an older randomized placebo-controlled trial in 45 women with fibromyalgia and low levels of IGF-1 (a peptide made in the liver in response to stimulation by growth hormone), those receiving subcutaneous growth hormone injections for nine months had greater reductions in tender points and fibromyalgia impact scores and were more likely to experience global improvement compared with those receiving placebo