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The dosage is escalated by adding 2.5 mg to the existing dosage every 4 weeks

For the 500-yr simulation, we calculate the DJFM TX10d and JJAS TX90d from daily data in the same way as for the observational data, but here the percentiles are calculated with respect to the full 500-yr period

Collectively, these late effects illustrate the narrow therapeutic window inherent to brachytherapy: the difference between a curative dose and the threshold for debilitating toxicity is small, particularly in patients with complex pelvic anatomy or advanced disease