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doi: 10.1007/s43440-023-00542-9, 4

CBS deficiency led to markedly homocysteine accumulation and severely decreased levels of cystathionine and cysteine, which was due to impaired homocysteine removal through the transsulfuration pathway [32]

DMT-1 is expressed at the brain endothelial and functions as a high-affinity transporter for non-transferrin-bound divalent cations, exhibiting a non-selective affinity for various divalent metal ions, including Mn [15, 133]