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FoB persist in the follicles in a quiescent state as they recirculate until activated by recognition of the antigen by their B cell receptors and the T cell-mediated cognate help, whereupon they proliferate and undergo germinal center (GC) reactions 6,17

10.1126/science.1523409 Science

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Qing-Bin Lu, [email protected] These authors have contributed equally to this work ORCID: Qing-Bin Lu, orcid.org/0000-0002-2804-0827 Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers