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Experimental studies have shown that metformin treatment can improve cognitive performance in female mice with APP transgenic models (180)

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doi: 10.1161/JAHA.113.000542

Composition and function of the human gut microbiota Although several bacterial species occupy the gut, most evidence point to the fact that total composition of the healthy gut microbiota largely comprises species from the Bacteroidetes (predominantly gram negative Bacteroides or Prevotella) and the Firmicutes (predominantly gram positive Clostridium and Lactobacillus ) phyla, respectively (Qin et al., 2010