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251 Notably, PHDs use iron, ascorbate, oxygen, and 2-oxoglutarate to hydroxylate and inhibit HIF1, while ROS disrupt these interactions, causing HIF1 accumulation

Wiley Interdiscip Rev Syst Biol Med (2020) 12(4):e1483

Among the many putative ncRNA-IGF pathways discussed in this review, some are supported by patient survival analyses and tissue investigations

However, glutathione depletion results in GPX4 inactivation, which subsequently increases lipid peroxidation and ultimately induces ferroptosis (Zhang et al., 2022)