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When ROS increases, the synthesis of mitochondrial fusion-related proteins will be inhibited, thus promoting mitochondrial fission, which in turn may lead to more ROS production and severe mitochondrial dysfunction

Administration of PLX3397 to mice For pharmacological ablation of microglia, PLX3397 was administrated to mice by supplementation (290 mg/kg of PLX3397 (#C-1271

Fredriksson L, Wink S, Herpers B et al (2014) Drug-induced endoplasmic reticulum and oxidative stress responses independently sensitize toward TNF-mediated hepatotoxicity

doi: 10.1016/j.matdes.2023.112231 123 LoiseauA.AsilaV.Boitel-AullenG.LamM.SalmainM.BoujdayS