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doi: 10.1038/s41580-020-00324-8 27 DixonSJLembergKMLamprechtMRSkoutaRZaitsevEMGleasonCEet al

Interestingly, the study appears to demonstrate a clear dissociation between mechanical hypersensitivity and ICSS behavior, suggesting that mechanical hypersensitivity, a common measure in animal models of pain, may not reflect the affective or hedonic aspects of pain that impact ICSS