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Case reports describe new moles appearing and rapid changes in old ones after only one or two doses

Multiple or large CMN, for example, may be associated with CNS structural and/or functional abnormalities, and/or a number of different tumors including lipoma, rhabdomyosarcoma, and others [28, 29], supporting an early embryonic onset of a pathogenic mutation [27, 30,31,32]

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solar keratoses and IEC, can be removed with a freeze lasting a few seconds, however, superficial BCC requires longer and repeat applications aiming for a cumulative tumour freeze-time of approximately 60 seconds