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Similarly, the increase observed in various metabolites participating in the phosphocreatine system (creatine, creatinine) and niacin metabolism (niacinamide, N1-methyl-4-pyridone-3-carboxamide), which are responsible for managing the energy pool (i.e., ATP, NADPH), further supports profound failures in catabolism

A conjugate according to claim 1, wherein the ligand is a ligand that specifically binds to or is endocytosed or transcytosed into or through a BCEC or MDCK target cell at a rate that is at least 10% enhanced as compared control conditions selected from a) cells lacking expression of GSH transporters

doi: 10.1038/s41390-022-02295-2 2 AslamSStricklandTMolloyEJ

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