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For the apo state, -alanine- and P4S-bound hTauT, movie stacks were obtained using EPU software (Thermo Fisher Scientific) in super-resolution mode at a magnification of 81,000 with a calibrated pixel size of 0.5335 and a defocus range of 1.5 m to 1.8 m

The architecture of the base multi-particulate formulation comprised a microcrystalline core layered with hydrocortisone, a sustained-release coat of ammonia methacrylate copolymer, type A and type B, and an outer enteric polymer coat of methacrylic acid-methyl methacrylate copolymer (Fig

237 Targeting glutaminase with inhibitors such as telaglenastat (CB-839) in combination with radiotherapy and TMZ is a promising strategy that is currently under clinical investigation