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- Liposomal delivery enables glutathione to bypass the harsh digestive system, allowing for better absorption and delivery to the liver, the primary site of detoxification

Conventional DMARDs (e.g., methotrexate, leflunomide, sulfasalazine): Methotrexate slows joint damage and suppresses inflammation but causes hepatic toxicity and bone marrow suppression, leading to 30% treatment discontinuation within one year (8)

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Its critical role as a detoxifying agent and free radical scavenger makes it a master antioxidant .* The glutathione level can decrease in our body due to several factors, including aging, poor diet, lifestyle choices, and certain pathological conditions