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DNA binding protein HMGB1 secreted by activated microglia promotes the apoptosis of hippocampal neurons in diabetes complicated with OSA

A dysregulated and functionally impaired microbiome tend to promote chronic low-grade inflammation, immune dysregulation, oxidative stress, DNA damage and metabolic rewiring, contributing to the carcinogenic effects of hr-HPV integrating oncogenes into the host genome

74 SchneckR.Plumas-MartyB.TaibiA.Billaut-MulotO.LoyensM.Gras-MasseH.et al (1994)

Arousal induces NO release, cGMP activation, and the PK1 cascade, which hyperpolarize smooth muscle cells and reduce cytosolic calcium concentration