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Decreased 2,3-DPG causes a decrease in oxygen availability, which can lead to diminished physical activity capacity and, consequently, lower energy expenditure (157)

The ET B receptor induces relaxation in endothelial cells

doi: 10.1016/j.cmet.2016.06.004 41 YukJMParkEJKimISJoEK

For example, TLR4 recognizes bacterial lipopolysaccharides (LPS) and activates the NF-B and interferon pathways, driving proinflammatory cytokine production [54]