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However, the prognosis of advanced HCC remains poor, and therefore, there is a constant need for further research and new developments in treatment strategies [91]

In addition, PXR can inhibit CYP7A1 transcription through SHP, which is a key activator of the activation of CYP7A1 gene in the hepatocytes (84)

Tracy References: Teskey et al Glutathione as a marker for human disease Adv Clin Chem 2018;87:141-159 DOI: 10.1016/bs.acc.2018.07.004 Richie J et al Randomized controlled trial of oral glutathione supplementation on body stores of glutathione EurJ Nutr

support this, demonstrating atorvastatin's effectiveness in reducing IOP in ocular hypertension models (205)