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10.1007/s11064-018-2651-3 214 LiuY.WangT.JiY

Biochem Biophys Res Commun 379: 887891

GPCRs that are agonist-activated promote the synthesis of guanine triphosphate (GTP), which when bound to the G-protein causes the Ga and Gbc subunits to separate, which in turn can activate signaling proteins downstream [52]

Both produce therapeutic CNS concentrations, but subcutaneous allows for longer intervals between observable plasma peaks, which may reduce variability in studies measuring acute cognitive effects