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Response: Commenters' suggestions that the policy changes on reopening ACO payment determinations apply to reopening requests for performance years prior to 2025, may reflect confusion over the difference between the effective date for the policies being finalized in this final rule and the timeframes for reopening payment determinations in accordance with 425.315(a) (as amended by this final rule), and the new process for ACOs to request reopening review under the provisions we are finalizing with this final rule in 425.315(b) (as described in section III.G.7.c.(2).(e) of this final rule)

The physiology, metabolism, and immune responses can differ significantly

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doi: 10.3390/antiox9060460