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In metabolic disease contexts, studies have found that supraphysiological doses of coenzyme Q 10 (CoQ 10 ) can specifically upregulate SQOR expression and simultaneously inhibit key enzymes (CBS and CSE) in the transsulfuration pathway, thereby reshaping the serinefolate cycle and nucleotide metabolism (Gonzlez-Garca et al., 2020)

Consequently, its activity reflects the cells energy state and redox balance and can modulate mitochondrial ROS production under conditions of high NADH/NAD + ratios or impaired electron flow