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) is one of the most important vegetables in the world, and more than 3.8 million hm 2 of pepper are grown worldwide [16], and peppers tend to accumulate heavy metals during growth, causing toxicity [17]

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The contents of Fe 2+ , Fe 3+ and total iron in the cartilage with OA injury are significantly higher than those in the cartilage without OA injury, suggesting iron deposition occurs in the cartilage during OA progression

This conjugation makes the toxins less harmful and easier to excrete