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Springer Deodhar A (2015) Dual energy X-ray absorptiometry in rheumatoid arthritis, atlas of rheumatoid arthritis

Studies show that symptoms can last at least 18 months for some people

Reactions that warrant attention include persistent swelling or redness lasting more than 24 hours, significant pain beyond the initial injection moment, the development of hard nodules that do not resolve within a day or two, fever or systemic symptoms following injection, or any sign of infection at the injection site including warmth, pus, or spreading redness

This study showed effects at very low concentrations (picomolar to nanomolar), which is encouraging for topical application