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Cagrilintide can increase the sensitivity of leptin receptors and potentiate leptin-induced activation of signal transducer and activator of transcription 3 (STAT3), a transcription factor that mediates leptins effects on gene expression (Lutz et al., 2015, Front Endocrinol (Lausanne))

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Ethics statement The animal study was reviewed and approved by Animal Ethical and Welfare Committee of Zhejiang Chinese Medical University