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We recently demonstrated increased CD38 expression in skin biopsies from patients with SSc, and correlation with clinical disease severity 24

What is known is that murine B1 cells are metabolically inflexible in the absence of autophagy, as B1 cell numbers are reduced, fat metabolism transcripts are down-regulated, and compensatory uptake in glucose is minimized following conditional deletion of the autophagy gene Atg7 (96)